Roebourne Regional Prison is located on Ngarluma land, in Roebourne, Western Australia.

Roebourne is the receival facility for adult men and women in the Pilbara region who are on remand, sentenced or returned to prison. Roebourne holds medium and minimum-security prisoners for longer periods, but maximum-security prisoners are only held on a short-term basis. It also hosts a Town Work Camp for trusted minimum-security prisoners.

Roebourne Regional Prison was opened in 1984. The facility replaced Roebourne Gaol which is now a tourist site in Roebourne town. The prison was originally a minimum-security prison and was converted to a medium-security prison in 1995.

The Town Work Camp adjacent to the prison was opened in June 2014, which replaced a smaller work camp at Millstream.